2. Neurological Disease

Neurological Disease

Neurological Disease

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A range of neurological disorders, including epilepsy and dystonia, may involve dysfunctional intracortical inhibition, and may respond to treatments that modify it. Parkinson’s is a neurodegenerative disease characterized by increased activity of GABA in basal ganglia and the loss of dopamine in nigrostriatum, associated with rigidity, resting tremor, gait with accelerating steps, and fixed inexpressive face. Neurological deficits, along with neuromuscular involvement, are characteristic of mitochondrial disease, and these symptoms can have a dramatic impact on patient quality of life. Neurological features may be manifold, ranging from neural deafness, ataxia, peripheral neuropathy, migraine, seizures, stroke‐like episodes and dementia and depend on the part of the nervous system affected.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-W795507
    Cyanopindolol 69906-85-0 99.24%
    Cyanopindolol is an β3-adrenoceptor antagonist. Cyanopindolol is a potent and selective antagonist at the presynaptic serotonin autoreceptor in the rat brain cortex. Cyanopindolol has binding affinity for 5-HT1A and 5-HT1B receptor (Ki: 2.1 and 3 nM respectively).
    Cyanopindolol
  • HY-N0229S10
    L-Alanine-13C3,15N 202407-38-3 ≥98.0%
    L-Alanine-13C3,15N is the 13C- and 15N-labeled L-Alanine. L-Alanine is a non-essential amino acid, involved in sugar and acid metabolism, increases immunity, and provides energy for muscle tissue, brain, and central nervous system.
    L-Alanine-13C3,15N
  • HY-N0473S15
    L-Tyrosine-d3 71939-39-4 ≥99.0%
    L-Tyrosine-d3 is the deuterium labeled L-Tyrosine. L-Tyrosine is a non-essential amino acid which can inhibit citrate synthase activity in the posterior cortex.
    L-Tyrosine-d3
  • HY-W008253S
    5-Hydroxyindole-3-acetic acid-d2 56209-31-5 99.00%
    5-Hydroxyindole-3-acetic acid-d2 is the deuterium labeled 5-Hydroxyindole-3-acetic acid. 5-Hydroxyindole-3-acetic acid is the main metabolite of serotonin or metanephrines, which can be used as a biomarker of neuroendocrine tumors.
    5-Hydroxyindole-3-acetic acid-d2
  • HY-W008719S
    MPP+-d3(iodide) 207556-07-8 99.60%
    MPP+-d3 (iodide) is deuterium labeled MPP+ (iodide). MPP+ iodide, a toxic metabolite of the neurotoxin MPTP, causes symptom of Parkinson's disease in animal models by selectively destroying dopaminergic neurons in substantia nigra. MPP+ iodide is taken up by the dopamine transporter into dopaminergic neurons where it exerts its neurotoxic action on mitochondria by affecting complex I of the respiratory chain. MPP+ iodide is also a high affinity substrate for the serotonin transporter (SERT).
    MPP+-d3(iodide)
  • HY-W012722R
    4-Methyl-2-oxopentanoic acid (Standard) 816-66-0
    4-Methyl-2-oxopentanoic acid (Standard) is the analytical standard of 4-Methyl-2-oxopentanoic acid. This product is intended for research and analytical applications. 4-Methyl-2-oxopentanoic acid (α-Ketoisocaproic acid), an abnormal metabolite, is both a neurotoxin and a metabotoxin.
    4-Methyl-2-oxopentanoic acid (Standard)
  • HY-W014666R
    Xanthurenic acid (Standard) 59-00-7
    Xanthurenic acid (Standard) is the analytical standard of Xanthurenic acid. This product is intended for research and analytical applications. Xanthurenic acid is a putative endogenous Group II metabotropic glutamate receptor agonist, on sensory transmission in the thalamus.
    Xanthurenic acid (Standard)
  • HY-W011873S1
    Palmitoleic acid-d13 2692623-92-8 ≥99.0%
    Palmitoleic acid-d13 is the deuterium labeled Palmitoleic acid. Palmitoleic acid, a composition of fatty acid, is implicated in the prevention of death from cerebrovascular disorders in SHRSP rats.
    Palmitoleic acid-d13
  • HY-12510
    Methoxy-PEPy 524924-76-3 98.19%
    Methoxy-PEPy is a potent and highly selective mGlu5 receptor antagonist with IC50 of 1 nM.
    Methoxy-PEPy
  • HY-14260
    RS 8359 105365-76-2
    RS 8359 is a selective and reversible MAO-A inhibitor, with antidepressant activity.
    RS 8359
  • HY-14813
    Cutamesine 165377-43-5 99.18%
    Cutamesine (SA4503) is a potent and selective sigma 1 receptor agonist with an IC50 of 17.4 nM in guinea pig brain membranes. Cutamesine shows >100-fold less affinity for the sigma 2 receptor (IC50 of 1784 nM). Cutamesine has antidepressant effects.
    Cutamesine
  • HY-18689
    SYM2206 173952-44-8 99.83%
    SYM2206 is a potent and non-competitive AMPA receptor antagonist, with an IC50 of 1.6 μM. SYM2206 blocks Nav1.6-mediated persistent currents.
    SYM2206
  • HY-33169
    1,2,3,4-Tetrahydro-β-carboline-1-carboxylic acid 6649-91-8 99.47%
    1,2,3,4-Tetrahydro-β-carboline-1-carboxylic acid is a chemical used on the study of neurodegenerative diseases.
    1,2,3,4-Tetrahydro-β-carboline-1-carboxylic acid
  • HY-76612
    SB-408124 Hydrochloride 1431697-90-3 98.79%
    SB-408124 Hydrochloride is a selective non-peptide orexin receptor 1 (OX1) receptor antagonist with Kis of 57 nM and 27 nM in whole cell and membrane, respectively. SB-408124 Hydrochloride exhibits 50-fold selectivity over OX2 receptor.
    SB-408124 Hydrochloride
  • HY-B0459
    Scopine 498-45-3 ≥98.0%
    Scopine is the metabolite of anisodine, which is a α1-adrenergic receptor agonist and used in the treatment of acute circulatory shock.
    Scopine
  • HY-B0551
    Doxapram 309-29-5 99.70%
    Doxapram inhibits TASK-1, TASK-3, TASK-1/TASK-3 heterodimeric channel function with EC50 of 410 nM, 37 μM, 9 μM, respectively.
    Doxapram
  • HY-B1132
    Clidinium bromide 3485-62-9 ≥98.0%
    Clidinium bromide is a quaternary amine antimuscarinic agent. Clidinium bromide may help symptoms of cramping and abdominal/stomach pain by decreasing stomach acid, and slowing the intestines in vivo.
    Clidinium bromide
  • HY-B2113
    Bromisoval 496-67-3 99.81%
    Bromisoval has anti-inflammatory effects.
    Bromisoval
  • HY-B2121
    6-Methoxy-2-naphthoic acid 2471-70-7 ≥98.0%
    6-Methoxy-2-naphthoic acid (6-MNA) is the active metabolite of Nabumetone (HY-B0559). 6-Methoxy-2-naphthoic acid is also an inhibitor of COX-1 and COX-2. 6-Methoxy-2-naphthoic acid can inhibit the synthesis of gastric mucosal prostaglandin E2. 6-Methoxy-2-naphthoic acid can be used in the research of inflammation and pain-related diseases. In addition, 6-Methoxy-2-naphthoic acid is an impurity in Naproxen (HY-15030) and can also be used in the synthesis of other active compounds.
    6-Methoxy-2-naphthoic acid
  • HY-NP192
    Sericin
    Sericin is a type of spherical protein that can be isolated from silk cocoons. Sericin is a cognitive enhancer and pain reliever. Sericin is a fetal bovine serum- or DMSO-replacing cryoprotectant agent. Sericin reduces oxidative stress and reactive oxygen species (ROS). Sericin can repair wounds by producing collagen. Sericin has antioxidant, anti-diabetic, anti-hyperlipidemic, anti-inflammatory, skin moisturizer, wound healing, antibacterial, antimicrobial, and anti-tumor protector.
    Sericin
Cat. No. Product Name / Synonyms Application Reactivity